Metrics details. Metaplastic breast cancer MpBC is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by the histological presence of at least two cellular types, typically epithelial and mesenchymal components. There are currently no standardized treatment guidelines specifically for MpBC. Some of these molecular alterations have been studied as therapeutic targets, in both the preclinical and clinical setting.
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Metaplastic Breast Cancer
Please understand that our phone lines must be clear for urgent medical care needs. When this changes, we will update this web site. Please know that our vaccine supply is extremely small. It differs from the more common kinds of breast cancer in both its makeup and in the way it behaves. Like invasive ductal cancer, metaplastic breast cancer begins in the milk duct of the breast before spreading to the tissue around the duct. What makes a metaplastic tumor different is the kinds of cells that make up the tumor. When the cells of an invasive ductal tumor are examined under a microscope, they appear abnormal, but still look like ductal cells.
A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations
Metaplastic carcinoma , otherwise known as metaplastic carcinoma of the breast MCB , is a heterogeneous group of cancers that exhibit varied patterns of metaplasia and differentiation along multiple cell lines. IDC , and shares similar treatment approaches. MCB tumors are typically estrogen receptor ER , progesterone receptor PR , and human epidermal growth factor-2 HER-2 negative, meaning hormone therapy is generally not an effective treatment option, which correlates to a relatively poor prognosis. Owing to its relatively recent pathological distinction, multiple classification systems have been adopted for MCB among different organizations and research groups.
Metaplastic carcinoma of the breast, a neoplasm with both epithelial and mesenchymal elements, represents less than 1 per cent of all breast cancer. We reviewed the records of all patients diagnosed with localized metaplastic breast cancer from to at our institution. We identified 21 patients.